17beta, 19-Dihydroxy-1alpha,7alpha-dimethyl-4-androsten-3-one diacetate → 17beta,19-Dihydroxy-1alpha,7alpha-dimethyl-4-androsten-3-one

Participants

Reaction Steps

17β, 19-Dihydroxy-1α,7α-dimethyl-4-androsten-3-one diacetate is dissolved under nitrogen in a sodium methoxide methanol solution at 0° C. and stirred at room temperature for about 2 hours. The solution is poured onto water and the solid collected by filtration. Recrystallization of the solid from acetonitrile yields the desired 17β,19-dihydroxy-1α,7α-dimethyl-4-androsten-3-one.

Provenance & Evidence