Dimethylamine → 2-Amino-N,N-dimethyl-5-methoxy-benzylamine

HRID 371872Notes

Reaction equation

HRID 371872 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH2:4]O.S(Cl)(Cl)=O.[CH3:16][NH:17][CH3:18]>C(Cl)Cl>[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH2:4][N:17]([CH3:18])[CH3:16]

Participants

5

Reactant 3

HCID 674DimethylamineHCID 24386Thionyl ChlorideHCID 13756678(2-Amino-5-methoxyphenyl)methanol

Product 1

HCID 203190282-Amino-N,N-dimethyl-5-methoxy-benzylamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Amino-N,N-dimethyl-5-methoxy-benzylamine was prepared from 2-amino-5-methoxy-benzyl alcohol, thionyl chloride and dimethylamine analogous to Example 1. Proof of structure by IR-, UV- and NMR-spectra. IR-spectrum (methylenechloride): 3280 cm-1NH2 ; 3420 cm-1NH2 ; 2780 cm-1N(CH3)2 ; 2830 cm-1OCH3 ; 1600 cm-1C=C.

Sources & evidence

ORD record
ord-368b7ede9f9147e09b447a441c60cf3a
Source dataset
uspto-grants-1978_05
Patent number
USRE029628

Reaction notes

Loading…