Morpholine → N-(2-Amino-5-methoxy-benzyl)-morpholine

HRID 371878Notes

Reaction equation

HRID 371878 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH2:4]O.S(Cl)(Cl)=O.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>C(Cl)Cl>[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH2:4][N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 24386Thionyl ChlorideHCID 13756678(2-Amino-5-methoxyphenyl)methanol

Product 1

HCID 20318983N-(2-Amino-5-methoxy-benzyl)-morpholine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-(2-Amino-5-methoxy-benzyl)-morpholine was prepared from 2-amino-5-methoxy-benzyl alcohol, thionyl chloride and morpholine analogous to Example 1. Proof of structure by IR- and UV-spectra. IR-spectrum (methylenechloride) 3280 cm-1NH2 ; 3410 cm-1NH2 ; 2830 cm-1OCH3 ; 2800 cm-1N-alkyl; 1500 cm-1C=C; 1600 cm -1 C=C.

Sources & evidence

ORD record
ord-9a7a426fd34c4806a4364818591e41c4
Source dataset
uspto-grants-1978_05
Patent number
USRE029628

Reaction notes

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