Hydrochloric Acid → HCID 20319038, compound

HRID 371885Notes

Reaction equation

HRID 371885 reaction equation
[NH2:1][C:2]1[C:11]([Br:12])=[CH:10][C:9]([C:13]([O:15]C)=[O:14])=[CH:8][C:3]=1[CH2:4][NH:5][CH2:6][CH3:7].Cl>>[NH2:1][C:2]1[C:11]([Br:12])=[CH:10][C:9]([C:13]([OH:15])=[O:14])=[CH:8][C:3]=1[CH2:4][NH:5][CH2:6][CH3:7]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 53728375HCID 53728375, compound

Product 1

HCID 20319038HCID 20319038, compound

Conditions

Temperature
-15 °C

Procedure

2.7 gm of 2-amino-3-bromo-5-carbomethoxy-N-ethyl-benzylamine were boiled for 35 minutes with 65 ml of 6 N hydrochloric acid. Thereafter, upon cooling the reaction solution to -15° C, N-ethyl-2-amino-3-bromo-5-carboxy-benzylamine hydrochloride crystallized out and was recrystallized from ethanol/ether, whereupon it had a melting point of 261° C (decomp.).

Workup

  1. customN-ethyl-2-amino-3-bromo-5-carboxy-benzylamine hydrochloride crystallized out
  2. customwas recrystallized from ethanol/ether, whereupon it

Sources & evidence

ORD record
ord-bb561db46bc949af882e6ad99280e4f6
Source dataset
uspto-grants-1978_05
Patent number
USRE029628

Reaction notes

Loading…