HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluorouracil → 1,3-Dibenzoyl-5-fluoropyrimidine-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluorouracil | HCID 3385 | — |
| Reactant | Benzoyl bromide | HCID 12056 | — |
| Reactant | 3-Benzoyl-5-fluoropyrimidine-2,4(1H,3H)-dione | HCID 12690827 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1,3-Dibenzoyl-5-fluoropyrimidine-2,4(1H,3H)-dione | HCID 12690829 | 11.7% |
Reaction Steps
In the same manner as described in Example 1 but using 2.6 g (0.02 mole) of 5-fluorouracil, 10 ml of absolute pyridine and 7.4 g (0.04 mole) of benzoyl bromide, 1.6 g of 3-N-benzoyl-5-fluorouracil (yield, 34%) and 270 mg of 1,3-di-N-benzoyl-5-fluorouracil (yield, 4%) were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04088646 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-e92f15ba59e240bd973280dbbd8f4cdf |
| Source note | uspto-grants-1978_05 |