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HRID371918

反应详情

EQUATION

反应方程式

HRID 371918 的结构方程式

REACTANTS

反应物

4
结构：CO
HCID887

Methanol

CH4O

结构：O
HCID962

Water

H2O

结构：CCNN
HCID29062

Ethylhydrazine

C2H8N2

结构：CCOC(=O)c1c(C)nc(Cl)c([N+](=O)[O-])c1Cl
HCID12387594

Ethyl 4,6-dichloro-2-methyl-5-nitropyridine-3-carboxylate

C9H8Cl2N2O4

PRODUCTS

生成物

1
结构：CCNNc1nc(C)c(C(=O)OCC)c(Cl)c1[N+](=O)[O-]
HCID86734417

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

27.9 g. of 4,6-Dichloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester (0.2 mol.) are dissolved in about 100 ml. of methanol and 20 ml. of water. 15 g. of triethylamine are added and at 25°-30° 4.5 g. ethyl hydrazine are dropped in with stirring. After the addition is complete, stirring is continued for 1 additional hour. On cooling, 4-chloro-6-(1-ethyl)hydrazino-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester precipitates, yield 19.7 g. (65%) m.p. 117°-120°.

WORKUP

后处理

  1. additionAfter the addition
  2. stirringstirring
  3. temperatureOn cooling
  4. custom4-chloro-6-(1-ethyl)hydrazino-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester precipitates