Acetyl chloride → HCID 20352244, compound

HRID 371951Notes

Reaction equation

HRID 371951 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]23[CH2:14][CH:13]2[CH2:12][NH:11][CH2:10]3)=[CH:5][CH:4]=1.[C:15](Cl)(=[O:17])[CH3:16]>C1C=CC=CC=1.C(=O)([O-])[O-].[Na+].[Na+]>[C:15]([N:11]1[CH2:12][CH:13]2[C:9]([C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=3)([CH2:14]2)[CH2:10]1)(=[O:17])[CH3:16]

Participants

5

Reactant 2

HCID 6367Acetyl chlorideHCID 127198551-(4-Methoxyphenyl)-3-azabicyclo[3.1.0]hexane

Product 1

HCID 20352244HCID 20352244, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 10340Sodium CarbonateSolvent

Procedure

To a stirred mixture of 1-(p-methoxyphenyl)-3-azabicyclo[3.1.0]hexane in benzene and aqueous sodium carbonate is added acetyl chloride and the mixture is stirred at ambient temperature for 18 hours. Benzene is removed by evaporation under reduced pressure, and filtration of the residual mixture gives 3-acetyl-1-(p-methoxyphenyl)-3-azabicyclo[3.1.0]hexane.

Workup

  1. customBenzene is removed by evaporation under reduced pressure, and filtration of the residual mixture

Sources & evidence

ORD record
ord-ed16a27b620341238b26e7bb977b0c6d
Source dataset
uspto-grants-1978_05
Patent number
US04088652

Reaction notes

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