反应详情

A solution of sodium nitrite (0.82 g, 12 mmol) in water (10 ml) was added dropwise to a stirred suspension of 3-amino-4-(2-methylphenylamino)quinoline (2.0 g,8 mmol) in 2M HCl (80 ml) at 0.5°. The solid gradually dissolved to give a pale orange solution which deposited a solid after about 1 hour. After warming to room temperature the solid was collected, washed with water and recrystallised from aqueous ethanol with charcoaling, to give the title compound as a white solid (0.55 g, 26%), m.p. 140°-142° .

1. dissolutionThe solid gradually dissolved
2. customto give a pale orange solution which
3. customafter about 1 hour
4. customwas collected
5. washwashed with water
6. customrecrystallised from aqueous ethanol with charcoaling