HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Tocopheryl Nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Nicotinic Acid | HCID 938 | — |
| Reactant | DL-alpha-Tocopherol | HCID 2116 | — |
| Reactant | Nicotinoyl chloride | HCID 82604 | — |
| Reactant | Nicotinic anhydride | HCID 85607 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Tocopheryl Nicotinate | HCID 27990 | — |
Reaction Steps
More specifically, dl-α-tocopherol is reacted with a reactive derivative of nicotinic acid such as nicotinic anhydride or nicotinic chloride in the presence of a hydrochloride and pyridine, and the resulting reaction product is post-treated and purified by column chromatography, whereby pure dl-α-tocopheryl nicotinate is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04088778 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-756ef38d6ddc4036af461588bfab451a |
| Source note | uspto-grants-1978_05 |