HRID372027

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID938

Nicotinic acid

C6H5NO2

结构：Cc1c(C)c2c(c(C)c1O)CCC(C)(CCCC(C)CCCC(C)CCCC(C)C)O2

HCID2116

(+/-)-alpha-Tocopherol

C29H50O2

HCID82604

Nicotinoyl chloride

C6H4ClNO

HCID85607

Nicotinic anhydride

C12H8N2O3

PRODUCTS

生成物

结构：Cc1c(C)c2c(c(C)c1OC(=O)c1cccnc1)CC[C@@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)O2

HCID27990

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

More specifically, dl-α-tocopherol is reacted with a reactive derivative of nicotinic acid such as nicotinic anhydride or nicotinic chloride in the presence of a hydrochloride and pyridine, and the resulting reaction product is post-treated and purified by column chromatography, whereby pure dl-α-tocopheryl nicotinate is obtained.

WORKUP

后处理

customthe resulting reaction product
additionis post-treated
custompurified by column chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-756ef38d6ddc4036af461588bfab451a
来源数据集: uspto-grants-1978_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04088778
来源说明: uspto-grants-1978_05

反应 SMILES

[CH3:1][C:2]1[C:11]([CH3:12])=[C:10]2[C:5]([CH2:6][CH2:7][C:8]([CH2:14][CH2:15][CH2:16][CH:17]([CH2:19][CH2:20][CH2:21][CH:22]([CH2:24][CH2:25][CH2:26][CH:27]([CH3:29])[CH3:28])[CH3:23])[CH3:18])([CH3:13])[O:9]2)=[C:4]([CH3:30])[C:3]=1[OH:31].[C:32](O)(=[O:39])[C:33]1[CH:38]=[CH:37][CH:36]=[N:35][CH:34]=1.C(OC(=O)C1C=CC=NC=1)(=O)C1C=CC=NC=1.C(Cl)(=O)C1C=CC=NC=1.Cl>N1C=CC=CC=1>[CH3:12][C:11]1[C:2]([CH3:1])=[C:3]([O:31][C:32]([C:33]2[CH:38]=[CH:37][CH:36]=[N:35][CH:34]=2)=[O:39])[C:4]([CH3:30])=[C:5]2[CH2:6][CH2:7][C@:8]([CH2:14][CH2:15][CH2:16][C@@H:17]([CH2:19][CH2:20][CH2:21][C@@H:22]([CH2:24][CH2:25][CH2:26][CH:27]([CH3:29])[CH3:28])[CH3:23])[CH3:18])([CH3:13])[O:9][C:10]=12