反应详情

A mixture of 1.5 g of the product of Example 1, 100 ml of dimethylformamide and 3 g of cuprous cyanide was refluxed for 24 hours and the reaction mixture was taken up in 400 ml of water and 400 ml of ethyl acetate, filtered and extracted with ethyl acetate. After drying and filtering, the solvents were eliminated under reduced pressure at a temperature of about 60° C. to obtain after chromatography on silica (essence G: 80/ethyl acetate: 20) 1.03 g of the expected product melting at 116° C.

1. temperaturewas refluxed for 24 hours
2. filtration400 ml of ethyl acetate, filtered
3. extractionextracted with ethyl acetate
4. customAfter drying
5. filtrationfiltering
6. customwere eliminated under reduced pressure at a temperature of about 60° C.