反应详情

A mixture of 1 g of the product of Example 6, 20 ml of methylene chloride and 4 ml of trifluoroacetic acid was stirred at room temperature for 4 hours and the solvent and the reagent were eliminated at 30° C. under reduced pressure. The residue was taken up in a mixture of 40 ml of 1N sodium hydroxide and 20 ml of ether and extracted with 1N sodium hydroxide. The aqueous phase was acidified with concentrated hydrochloric acid and extracted with ether after saturation with sodium chloride. After drying and filtering, the solvent was eliminated at 50° C. under reduced pressure.

1. customwere eliminated at 30° C. under reduced pressure
2. extractionextracted with 1N sodium hydroxide
3. extractionextracted with ether after saturation with sodium chloride
4. customAfter drying
5. filtrationfiltering
6. customwas eliminated at 50° C. under reduced pressure