反应详情

The 2-methyl-3,5-dihydro-5,9b-o-benzenobenz[e]isoindol-1-(2H)-one starting material was prepared as follows: a mixture of 25 g of 9-anthroic acid and 75 ml of thionyl chloride is heated under reflux for 1 hour. The excess thionyl chloride is removed under vacuum (30 mm; 90° bath temperature); 50 ml of toluene is added and the mixture is concentrated again. This operation is repeated once more to give 28.3 g of 9-anthroyl chloride as a very moisture-sensitive, yellow solid.

1. temperatureis heated
2. temperatureunder reflux for 1 hour
3. customThe excess thionyl chloride is removed under vacuum (30 mm; 90° bath temperature)
4. addition50 ml of toluene is added
5. concentrationthe mixture is concentrated again