反应详情

A mixture of 2 g of the product of Stage D, 100 ml of tetrahydrofuran and 1 -g of [tetra-bis(triphenylphosphine)] palladium was added to 35.9 ml of zinc 4-bromomethyl benzonitrile at ambient temperature and the mixture was refluxed for one hour. The mixture was allowed to return to ambient temperature, poured into water and extracted with ethyl acetate. The extracts were washed with a saturated aqueous solution of sodium chloride, dried, filtered and brought to dryness to obtain after chromatography on silica (ethyl acetate), 1.1 g of the expected product.

1. temperaturethe mixture was refluxed for one hour
2. customto return to ambient temperature
3. extractionextracted with ethyl acetate
4. washThe extracts were washed with a saturated aqueous solution of sodium chloride
5. customdried
6. filtrationfiltered