Tert-Butylamine → 2-Bromo-4-t-butylaminocarbonylthiazole

HRID 372187Notes

Reaction equation

HRID 372187 reaction equation
[Br:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([OH:9])=O)[N:6]=1.[C:10]([NH2:14])([CH3:13])([CH3:12])[CH3:11]>>[Br:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([NH:14][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:9])[N:6]=1

Participants

3

Reactant 2

HCID 6385Tert-ButylamineHCID 27632092-Bromo-1,3-thiazole-4-carboxylic acid

Product 1

HCID 156638042-Bromo-4-t-butylaminocarbonylthiazole

Procedure

Similarly, 2-bromo-4-t-butylaminocarbonylthiazole is prepared by following the same procedure but using 2-bromo-4-carboxythiazole in place of the 5-position isomer. Similarly, by replacing t-butylamine with the amine reagents set forth in Preparation 2, the corresponding 2-bromo-4- and 5-substituted aminocarbonylthiazoles are respectively prepared.

Workup

  1. customset forth in Preparation 2

Sources & evidence

ORD record
ord-d1bdc0572c354093b2b2f143d054650b
Source dataset
uspto-grants-1978_05
Patent number
US04089865

Reaction notes

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