Hydrochloric Acid → 62435-92-1

HRID 372191Notes

Reaction equation

HRID 372191 reaction equation
[ClH:1].[C:2]([NH:6][CH2:7][CH:8]([OH:26])[CH2:9][O:10][C:11]1[S:12][C:13]([C:16]([NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH:23]([CH3:25])[CH3:24])=[O:17])=[CH:14][N:15]=1)([CH3:5])([CH3:4])[CH3:3]>C(OCC)C>[ClH:1].[C:2]([NH:6][CH2:7][CH:8]([OH:26])[CH2:9][O:10][C:11]1[S:12][C:13]([C:16]([NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH:23]([CH3:24])[CH3:25])=[O:17])=[CH:14][N:15]=1)([CH3:5])([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 173857HCID 173857, compound

Product 1

HCID 17385662435-92-1

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

This example illustrates methods of preparing hydrochloride addition salts of the invention. In this example 1 g. of 1-t-butylamino-3-(5-5'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol is dissolved in 10 ml. of ethyl ether at 20° C. A stream of gaseous anhydrous hydrogen chloride is passed over the surface of the solution until the supernatent liquid becomes colorless. The resulting precipitate is collected by filtration, washed with ethyl ether and then crystallized from methanol, containing 1% water and 1% acetone, affording crystalline 1-t-butylamino-3-(5-5'methylhexylaminocarbonylthiazol-2-oxy)-2-propanol hydrochloride.

Workup

  1. customat 20° C
  2. filtrationThe resulting precipitate is collected by filtration
  3. washwashed with ethyl ether
  4. customcrystallized from methanol
  5. additioncontaining 1% water and 1% acetone

Sources & evidence

ORD record
ord-c9030ac2f7ec4c669682ef8d42072c52
Source dataset
uspto-grants-1978_05
Patent number
US04089865

Reaction notes

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