O-Xylene → 3,4-Dihydro-2-methyl-3-oxo-4-(2-pyridyl-carbamoyl)-2H-thieno [2,3-e] 1,2-thiazine 1,1-dioxide

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Reaction Steps

0.3 G. of 3,4-dihydro-4-methoxycarbonyl-3-oxo-2H-thieno[ 2,3-e] 1,2-thiazine 1,1-dioxide and 0.13 g. of 2-aminopyridine are dissolved in 30 ml. of absolute xylene and the solution is heated for 1 hour under reflux. After cooling, the crystals are removed by filtration and recrystallized from glacial acetic acid. 3,4-Dihydro-2-methyl-3-oxo-4-(2-pyridyl-carbamoyl)-2H-thieno [2,3-e] 1,2-thiazine 1,1-dioxide, melting point 225° C. to 256° C. (decomposition), is obtained.

Provenance & Evidence