Benzamide → 4-Amino-1,2,3,4-tetrahydronaphthalen-1-ol

HRID 372400Notes

Reaction equation

ClC(Cl)(Cl)C(N)=O.[C:8](N)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C1(=O)[NH:21][C:20](=O)[C:19]2=CC=CC=[C:18]12>>[OH:15][CH:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:20]([NH2:21])[CH2:19][CH2:18]1

Participants

Reactant 3

HCID 2331Benzamide

HCID 6809Phthalimide

HCID 61144Trichloroacetamide

Product 1

HCID 203273134-Amino-1,2,3,4-tetrahydronaphthalen-1-ol

Procedure

Similarly, the corresponding trichloroacetamide, benzamide and phthalimide are hydrolyzed to afford the title compound.

Sources & evidence

ORD record: ord-4502d8f6646e4e39a95bdf9a49cc35a9
Source dataset: uspto-grants-1978_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04091018

Reaction notes

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