4-Fluorophenol → HCID 22767921, compound

HRID 372425Notes

Reaction equation

HRID 372425 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[C:10]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:11]=1[CH:12]=[O:13].[OH-].[Na+]>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:10]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:11]=2[CH:12]=[O:13])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 97324-FluorophenolHCID 14798Sodium HydroxideHCID 729332-Chloro-5-nitrobenzaldehyde

Product 1

HCID 22767921HCID 22767921, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

448 G. of 4-fluoro-phenol and 742 g. of 2-chloro-5-nitro-benzaldehyde are added to a solution of 184 g. of sodium hydroxide in 7.4 liters of water. The mixture is then left to cool to room temperature. The precipitate is removed by filtration, washed carefully with water, and there is obtained 2-(4-fluoro-phenoxy)-5-nitro-benzaldehyde, having a melting point of 125°-126° C.

Workup

  1. waitThe mixture is then left
  2. customThe precipitate is removed by filtration
  3. washwashed carefully with water

Sources & evidence

ORD record
ord-950b743091094f8cbc654ca4e6dc3df2
Source dataset
uspto-grants-1978_05
Patent number
US04091023

Reaction notes

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