1-Methylpiperazine → 1-[2-Chloro-10,11-dihydro-dibenz[b,f]oxepin-10-yl]-4-methyl-piperazine dihydrochloride

HRID 372440Notes

Reaction equation

HRID 372440 reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]2[O:6][C:7]3[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=3[C:9]([N:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:10][C:4]=2[CH:3]=1.C([O-])(=O)/C=C\C([O-])=O.[Cl:32]C1C=CC2OC3C=CC=CC=3C(=O)CC=2C=1.CN1CCNCC1>>[ClH:1].[ClH:32].[Cl:1][C:2]1[CH:23]=[CH:22][C:5]2[O:6][C:7]3[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=3[CH:9]([N:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)[CH2:10][C:4]=2[CH:3]=1

Participants

5

Reactant 4

HCID 531671-MethylpiperazineHCID 5288227Maleate(2-)HCID 127651152-Chlorodibenzo[b,f]oxepin-10(11h)-oneHCID 127651161-(2-Chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine

Product 1

HCID 227678371-[2-Chloro-10,11-dihydro-dibenz[b,f]oxepin-10-yl]-4-methyl-piperazine dihydrochloride

Procedure

The 1-[2-chloro-dibenz[b,f]oxepin-10-yl]-4-methyl-piperazine having a melting point of 119°-120° C. [maleate: melting point 200°-202° C (with decomposition)] used as the starting material can be prepared in analogous manner to that described in Example 14 from 2-chloro-10,11-dihydro-dibenz[b,f]oxepin-10-one and 1-methyl-piperazine.

Workup

  1. customcan be prepared in analogous manner to that

Sources & evidence

ORD record
ord-dd24865657944ebeb48d09df87d67f7d
Source dataset
uspto-grants-1978_05
Patent number
US04091023

Reaction notes

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