反应详情

N-methylhydroxylamine hydrochloride (14.6 g.) in 20 ml. of water was cooled in an ice-bath and treated with 20 g. of t-butyl azidoformate. A solution of 22.4 g. of sodium hydroxide in 80 ml. of water was added dropwise with stirring over 45 minutes while controlling the temperature below 10° C. The mixture was allowed to warm to room temperature with stirring over a 60 minute period after the addition during which time a little more sodium hydroxide solution and N-methyl hydroxylamine were added. The solution was extracted with 2 × 50 ml. of ether, and the extracts were discarded. The aqueous phase, with cooling, was adjusted to pH 3.5 with 6 N hydrochloric acid, and extracted with 5 × 60 ml. of ether. The combined ether extracts were dried over magnesium sulfate and evaporated to 16 g. of oily N-t-butoxycarbonyl-N-methyl hydroxylamine.

1. additiontreated with 20 g
2. customthe temperature below 10° C
3. stirringwith stirring over a 60 minute period
4. additionwere added
5. extractionThe solution was extracted with 2 × 50 ml
6. temperatureThe aqueous phase, with cooling
7. extractionextracted with 5 × 60 ml
8. dry with materialThe combined ether extracts were dried over magnesium sulfate
9. customevaporated to 16 g