HCID 3046871, compound → HCID 3046873, compound

HRID 372550Notes

Reaction equation

HRID 372550 reaction equation
[CH3:1][NH:2][CH:3]1[CH:9]=[CH:8][C:7]2[CH:10]=[CH:11][CH:12]=[CH:13][C:6]=2[CH2:5][CH2:4]1>C(O)C>[CH3:1][NH:2][CH:3]1[CH2:9][CH2:8][C:7]2[CH:10]=[CH:11][CH:12]=[CH:13][C:6]=2[CH2:5][CH2:4]1

Participants

3

Reactant 1

HCID 3046871HCID 3046871, compound

Product 1

HCID 3046873HCID 3046873, compoundYield 84.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3.4 g of 7-methylamino-6,7-dihydro [5H] benzocycloheptene, 200 ml of ethanol and 3.4 g of 10% palladized carbon was maintained under a hydrogen atmosphere until absorption ceased and was then filtered. The filtrate was evaporated to dryness under reduced pressure to obtain 2.9 g of 7-methylamino-6,7,8,9-tetrahydro [5H] benzocycloheptene. The said product was dissolved in 300 ml of ether and an ether solution saturated with hydrogen chloride was added. The mixture was filtered and the recovered precipitate was crystallized from an 8-2 ethyl acetate-methanol mixture to obtain 2.6 g of the hydrochloride of 7-methylamino-6,7,8,9-tetrahydro [5H] benzocycloheptene melting at 270° C.

Workup

  1. temperaturewas maintained under a hydrogen atmosphere until absorption
  2. filtrationwas then filtered
  3. customThe filtrate was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-308c2299364c45c9b0ccfca5627927a3
Source dataset
uspto-grants-1978_05
Patent number
US04091115

Reaction notes

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