HCID 3046871, compound → HCID 3046873, compound

Participants

Reaction Steps

A mixture of 3.4 g of 7-methylamino-6,7-dihydro [5H] benzocycloheptene, 200 ml of ethanol and 3.4 g of 10% palladized carbon was maintained under a hydrogen atmosphere until absorption ceased and was then filtered. The filtrate was evaporated to dryness under reduced pressure to obtain 2.9 g of 7-methylamino-6,7,8,9-tetrahydro [5H] benzocycloheptene. The said product was dissolved in 300 ml of ether and an ether solution saturated with hydrogen chloride was added. The mixture was filtered and the recovered precipitate was crystallized from an 8-2 ethyl acetate-methanol mixture to obtain 2.6 g of the hydrochloride of 7-methylamino-6,7,8,9-tetrahydro [5H] benzocycloheptene melting at 270° C.

Provenance & Evidence