Isopropylamine → HCID 54138641, compound

HRID 372575Notes

Reaction equation

HRID 372575 reaction equation
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH:8]=[CH:9][C:10]([OH:12])=O)=[O:7])=[CH:4][CH:3]=1.C(OC(Cl)=O)C.C(N(CC)CC)C.[CH:28]([NH2:31])([CH3:30])[CH3:29]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6](=[O:7])[CH:8]=[CH:9][C:10]([NH:31][CH:28]([CH3:30])[CH3:29])=[O:12])=[CH:13][CH:14]=1

Participants

6

Reactant 4

HCID 6363IsopropylamineHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 346434-(4-Chlorophenyl)-4-oxobut-2-enoic acid

Product 1

HCID 54138641HCID 54138641, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

The precursor 4-(4-chlorophenyl)-N-(1-methylethyl)-4-oxo-2-butenamide (7A) was prepared by the procedure shown in the previous examples by treating 1A with ethylchloroformate and triethylamine in toluene at 0°, then adding at 0° a solution of isopropylamine in toluene. 7A was obtained as a solid, m.p.: 162°-163°. It was converted to 7 by treatment with hydrogen perioxide, by the procedure described in Example 1, 7 being obtained as a solid, m.p.: 128-129°.

Workup

  1. customThe precursor 4-(4-chlorophenyl)-N-(1-methylethyl)-4-oxo-2-butenamide (7A) was prepared by the procedure

Sources & evidence

ORD record
ord-a839d90c75034284af883d2450f3036a
Source dataset
uspto-grants-1978_05
Patent number
US04091221

Reaction notes

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