反应详情

To a stirred solution of 4.3 grams of 4,6-dichloro-2-isopropylamino-5-pyrimidinecarbonitrile in 125 ml of diethyl ether was added dropwise 2.6 grams of diethylamine. Upon complete addition, the reaction mixture was stirred at room temperature for 1.5 hours. The reaction mixture was washed with water. The diethyl ether layer was separated and dried over magnesium sufate. The mixture was filtered, and the filtrate was evaporated under reduced pressure to a residue. The residue was recrystallized from methylcyclohexane to give 2.5 grams of 4-chloro-6-diethylamino-2-isopropylamino-5-pyrimidinecarbonitrile; mp, 74°-76°.

1. additionUpon complete addition
2. washThe reaction mixture was washed with water
3. customThe diethyl ether layer was separated
4. dry with materialdried over magnesium sufate
5. filtrationThe mixture was filtered
6. customthe filtrate was evaporated under reduced pressure to a residue
7. customThe residue was recrystallized from methylcyclohexane