Methylamine → 4-Chloro-2-isopropylamino-6-methylamino-5-pyrimidinecarbonitrile

HRID 372647Notes

Reaction equation

HRID 372647 reaction equation
[CH3:1]N.Cl[C:4]1[C:9]([C:10]#[N:11])=[C:8]([Cl:12])[N:7]=[C:6]([NH:13][CH2:14][CH3:15])[N:5]=1.[CH:16]([NH2:19])(C)C>>[Cl:12][C:8]1[C:9]([C:10]#[N:11])=[C:4]([NH:19][CH3:16])[N:5]=[C:6]([NH:13][CH:14]([CH3:15])[CH3:1])[N:7]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 6363IsopropylamineHCID 205102564,6-Dichloro-2-ethylamino-5-pyrimidinecarbonitrile

Product 1

HCID 205102014-Chloro-2-isopropylamino-6-methylamino-5-pyrimidinecarbonitrile

Procedure

This compound was prepared in the manner of Example XVII, substituting 4,6-dichloro-2-isopropylamino-5-pyrimidinecarbonitrile and aqueous 40% methylamine for 4,6-dichloro-2-ethylamino-5-pyrimidinecarbonitrile and isopropylamine. The reaction product was recrystallized from methylcyclohexane to give 4-chloro-2-isopropylamino-6-methylamino-5-pyrimidinecarbonitrile; mp, 170°-173°.

Workup

  1. customThis compound was prepared in the manner of Example XVII
  2. customThe reaction product was recrystallized from methylcyclohexane

Sources & evidence

ORD record
ord-d35cc72fac19424598babbf17cf6a262
Source dataset
uspto-grants-1978_05
Patent number
US04092150

Reaction notes

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