Isopropylamine → 4-Chloro-6-cyclopropylamino-2-(1-methylpropylamino)-5-pyrimidinecarbonitrile

HRID 372657Notes

Reaction equation

HRID 372657 reaction equation
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.Cl[C:6]1[C:11]([C:12]#[N:13])=[C:10]([Cl:14])[N:9]=[C:8]([NH:15][CH2:16][CH3:17])[N:7]=1.[CH:18](N)(C)[CH3:19]>>[Cl:14][C:10]1[C:11]([C:12]#[N:13])=[C:6]([NH:4][CH:1]2[CH2:3][CH2:2]2)[N:7]=[C:8]([NH:15][CH:16]([CH3:17])[CH2:18][CH3:19])[N:9]=1

Participants

4

Reactant 3

HCID 6363IsopropylamineHCID 69828CyclopropylamineHCID 205102564,6-Dichloro-2-ethylamino-5-pyrimidinecarbonitrile

Product 1

HCID 205102624-Chloro-6-cyclopropylamino-2-(1-methylpropylamino)-5-pyrimidinecarbonitrile

Procedure

4-Chloro-6-cyclopropylamino-2-(1-methylpropylamino)-5-pyrimidinecarbonitrile was prepared by the method of Example XVII, substituting 4,6-dichloro-2-(1-methylpropylamino)-5-pyrimidinecarbonitrile and cyclopropylamine for 4,6-dichloro-2-ethylamino-5-pyrimidinecarbonitrile and isopropylamine. The reaction product was recrystallized from methylcyclohexane to give 4-chloro-6-cyclopropylamino-2-(1-methylpropylamino)-5-pyrimidinecarbonitrile; mp, 112°-114°.

Workup

  1. custom4-Chloro-6-cyclopropylamino-2-(1-methylpropylamino)-5-pyrimidinecarbonitrile was prepared by the method of Example XVII
  2. customThe reaction product was recrystallized from methylcyclohexane

Sources & evidence

ORD record
ord-6e4e33cd3fbd4e72836b84754fe8e8c2
Source dataset
uspto-grants-1978_05
Patent number
US04092150

Reaction notes

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