HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → 4-Chloro-6-cyclopropylamino-2-(1-methylpropylamino)-5-pyrimidinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 4,6-Dichloro-2-ethylamino-5-pyrimidinecarbonitrile | HCID 20510256 | — |
| Product | 4-Chloro-6-cyclopropylamino-2-(1-methylpropylamino)-5-pyrimidinecarbonitrile | HCID 20510262 | — |
Reaction Steps
4-Chloro-6-cyclopropylamino-2-(1-methylpropylamino)-5-pyrimidinecarbonitrile was prepared by the method of Example XVII, substituting 4,6-dichloro-2-(1-methylpropylamino)-5-pyrimidinecarbonitrile and cyclopropylamine for 4,6-dichloro-2-ethylamino-5-pyrimidinecarbonitrile and isopropylamine. The reaction product was recrystallized from methylcyclohexane to give 4-chloro-6-cyclopropylamino-2-(1-methylpropylamino)-5-pyrimidinecarbonitrile; mp, 112°-114°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04092150 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-6e4e33cd3fbd4e72836b84754fe8e8c2 |
| Source note | uspto-grants-1978_05 |