反应详情

A mixture of (2S, 4S)-2-cyano-1-(4-nitrobenzyloxycarbonyl)-4-tritylthiopyrrolidine (2.00 g) and sodium azide (0.30 g) in dimethylformamide (20 ml) was stirred at 110°-120° C. for 9 hours in the presence of ammonium chloride (0.05 g). The mixture was concentrated under reduced pressure to give a residue. The residue was subjected to a column chromatography on silica gel (20 g) and eluted with a mixture of acetone and chloroform (10:90, V/V) to give (2S,4S)-1-(4-nitrobenzyloxycarbonyl) -2-(1H-tetrazol-5-yl)-4-tritylthiopyrrolidine (1.86 g).

1. concentrationThe mixture was concentrated under reduced pressure
2. customto give a residue
3. washeluted with a mixture of acetone and chloroform (10:90, V/V)