Ethyl chloroformate → HCID 20326483, compound

HRID 372699Notes

Reaction equation

HRID 372699 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11]([NH:14][NH2:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C(N(C(C)C)CC)(C)C.Cl[C:26]([O:28][CH2:29][CH3:30])=[O:27]>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:13]=[N:12][C:11]([NH:14][NH:15][C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 10928Ethyl chloroformateHCID 81531DiisopropylethylamineHCID 127268633-(4-Chlorophenyl)-6-hydrazinylpyridazine

Product 1

HCID 20326483HCID 20326483, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 1.0 g. of 6-(p-chlorophenyl)-3-hydrazinopyridazine and 0.65 g. of diisopropylethylamine in 25 ml. of dioxane are placed in a flask and warmed slightly. To this is added 0.5 g. (0.45 ml.) of ethyl chloroformate and the reaction is stirred for one hour. The dioxane is removed on a rotating evaporator and ethanol is added to the residue resulting in a precipitate. This precipitate is recrystallized from ethanol giving a yellow solid, m.p. 176°-180° C.

Workup

  1. additionA mixture of 1.0 g
  2. temperaturewarmed slightly
  3. additionTo this is added 0.5 g
  4. customThe dioxane is removed on a rotating evaporator and ethanol
  5. additionis added to the residue
  6. customresulting in a precipitate
  7. customThis precipitate is recrystallized from ethanol giving a yellow solid, m.p. 176°-180° C.

Sources & evidence

ORD record
ord-3404c6006f24493cadf0645903611eb5
Source dataset
uspto-grants-1978_05
Patent number
US04092311

Reaction notes

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