反应详情

A 24.4 g. portion of 5-methyl-6-phenyl-3(2H)-pyridazinone (prepared as described above) and 250 ml. of phosphorus oxychloride are heated on a steam bath for 6 hours. The reaction mixture is concentrated free of phosphorus oxychloride in vacuo and the concentrate is triturated with cold water. The resulting solid is filtered, washed with water, recrystallized twice from methanol and dried giving a white solid, m.p. 125°-126° C.

1. concentrationThe reaction mixture is concentrated free of phosphorus oxychloride in vacuo
2. customthe concentrate is triturated with cold water
3. filtrationThe resulting solid is filtered
4. washwashed with water
5. customrecrystallized twice from methanol
6. customdried
7. customgiving a white solid, m.p. 125°-126° C.