1-Butanol → HCID 20326505, compound

HRID 372715Notes

Reaction equation

HRID 372715 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]=[N:13][C:12](Cl)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1)#[N:2].[C:16]([O:20][C:21](=[O:24])[NH:22][NH2:23])([CH3:19])([CH3:18])[CH3:17].[CH2:25](O)CCC>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]=[N:13][C:12]([NH:23][NH:22][C:21]([O:20][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:24])=[CH:11][C:10]=2[CH3:25])=[CH:5][CH:4]=1)#[N:2]

Participants

4

Reactant 3

HCID 2631-ButanolHCID 70091tert-Butyl carbazateHCID 64052563-Chloro-6-(4-cyanophenyl)pyridazine

Product 1

HCID 20326505HCID 20326505, compound

Procedure

A mixture of 5.0 g. of 6-(p-cyanophenyl)-3-chloropyridazine, 8.71 g. of t-butylcarbazate and 100 ml. of butanol are heated at reflux for 3 hours. The solvent is removed on a rotating evaporator. Water is added, the resulting product is recovered by filtration, washed with water, recrystallized from methanol and dried yielding a product having a m.p. 169°-171° C.

Workup

  1. additionA mixture of 5.0 g
  2. temperatureat reflux for 3 hours
  3. customThe solvent is removed on a rotating evaporator
  4. additionWater is added
  5. filtrationthe resulting product is recovered by filtration
  6. washwashed with water
  7. customrecrystallized from methanol
  8. customdried
  9. customyielding a product

Sources & evidence

ORD record
ord-c516913a396b493e8b42d2093d3671e1
Source dataset
uspto-grants-1978_05
Patent number
US04092311

Reaction notes

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