1-Butanol → HCID 20326523, compound

HRID 372721Notes

Reaction equation

HRID 372721 reaction equation
C[C:2]1[CH:3]=[C:4](Cl)[N:5]=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1.[CH3:18][NH:19][NH2:20].[CH2:21](O)CCC>>[CH3:21][C:3]1[CH:2]=[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=2)[N:6]=[N:5][C:4]=1[N:19]([CH3:18])[NH2:20]

Participants

4

Reactant 3

HCID 2631-ButanolHCID 6061MethylhydrazineHCID 20398287HCID 20398287, compound

Product 1

HCID 20326523HCID 20326523, compound

Procedure

To an 8.0 g. portion of 5-methyl-6-(m-nitrophenyl)-3-chloropyridazine in 100 ml. of butanol is added 4.4 g. of methyl hydrazine. This reaction mixture is heated at reflux overnight and then cooled in an ice bath. The product which forms as a precipitate is collected by filtration, washed with butanol, water, dried and recrystallized from ethanol, m.p. 173°-174° C.

Workup

  1. temperatureThis reaction mixture is heated
  2. temperatureat reflux overnight
  3. temperaturecooled in an ice bath
  4. filtrationis collected by filtration
  5. washwashed with butanol, water
  6. customdried
  7. customrecrystallized from ethanol, m.p. 173°-174° C.

Sources & evidence

ORD record
ord-c0832bff14b649d09619e477660175ae
Source dataset
uspto-grants-1978_05
Patent number
US04092311

Reaction notes

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