反应详情

A mixture of 15.57 g. of ethyl 3-[6-(p-bromophenyl)-3-pyridazinyl]carbazate, 1.5 g. of 10% palladium on carbon catalyst, 200 ml. of ethanol and 60 ml. of ammonium hydroxide is shaken under 40 lb. of hydrogen pressure for 4 hours with external heating of bottle by means of a heated jacket. The reaction mixture is filtered and the filtrate concentrated to a solid which is washed with water to give 10.1 g. of cream colored crystals. Recrystallization by dissolving in ethanol and diluting with petroleum ether gave white crystals, m.p. 158°-160° C.

1. additionA mixture of 15.57 g
2. filtrationThe reaction mixture is filtered
3. concentrationthe filtrate concentrated to a solid which
4. washis washed with water
5. customto give 10.1 g
6. customRecrystallization
7. dissolutionby dissolving in ethanol
8. additiondiluting with petroleum ether
9. customgave white crystals, m.p. 158°-160° C.