反应详情

A mixture of 12.6 g. of 6-(α,α,α-trifluoro-m-tolyl)-3(2H)-pyridazinone and 200 ml. of phosphorus oxychloride is heated on a steam bath for 18 hours. The mixture is concentrated under vacuum and the residue triturated with cold water. The resulting solid is washed with water and air dried to give 13.5 g. of cream colored crystals, m.p. 131°-133° C. Recrystallization from methanol gives 6-(α,α,α-trifluoro-m-tolyl)-3-chloropyridazine as white crystals, m.p. 131°-133° C.

1. additionA mixture of 12.6 g
2. concentrationThe mixture is concentrated under vacuum
3. customthe residue triturated with cold water
4. washThe resulting solid is washed with water and air
5. customdried
6. customto give 13.5 g
7. customRecrystallization from methanol