1-Butanol → HCID 20326522, compound

HRID 372731Notes

Reaction equation

HRID 372731 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]=[N:13][C:12](Cl)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1)#[N:2].[CH3:16][NH:17][NH2:18].[CH2:19](O)CCC>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]=[N:13][C:12]([N:17]([CH3:16])[NH2:18])=[CH:11][C:10]=2[CH3:19])=[CH:5][CH:4]=1)#[N:2]

Participants

4

Reactant 3

HCID 2631-ButanolHCID 6061MethylhydrazineHCID 64052563-Chloro-6-(4-cyanophenyl)pyridazine

Product 1

HCID 20326522HCID 20326522, compound

Procedure

A mixture of 7.5 g. of 6-(p-cyanophenyl)-3-chloropyridazine, 3.5 g. of methylhydrazine and 75 ml. of n-butanol is refluxed for 3 hours. The mixture is cooled and filtered to give the product. Recrystallization from dioxane gives 6-(p-cyanophenyl)-5-methyl-3-(1-methylhydrazino)pyridazine as tan crystals, m.p. 149°-152° C.

Workup

  1. additionA mixture of 7.5 g
  2. temperatureThe mixture is cooled
  3. filtrationfiltered
  4. customto give the product
  5. customRecrystallization from dioxane

Sources & evidence

ORD record
ord-f5a3b4e5cee24c29b352fc488ea0515f
Source dataset
uspto-grants-1978_05
Patent number
US04092311

Reaction notes

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