反应详情

A mixture of 7.5 g. of 6-(p-cyanophenyl)-3-chloropyridazine, 3.5 g. of methylhydrazine and 75 ml. of n-butanol is refluxed for 3 hours. The mixture is cooled and filtered to give the product. Recrystallization from dioxane gives 6-(p-cyanophenyl)-5-methyl-3-(1-methylhydrazino)pyridazine as tan crystals, m.p. 149°-152° C.

1. additionA mixture of 7.5 g
2. temperatureThe mixture is cooled
3. filtrationfiltered
4. customto give the product
5. customRecrystallization from dioxane