Hydrochloric Acid → HCID 70619178, compound

HRID 372774Notes

Reaction equation

HRID 372774 reaction equation
[CH2:1]([O:8][C:9](=[O:37])[C@H:10]([CH2:33][CH2:34][S:35][CH3:36])[NH:11][C:12](=[O:32])[C@H:13]([CH2:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[NH:25][CH:24]=1)[NH:14]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:38]>O1CCOCC1>[ClH:38].[CH2:1]([O:8][C:9](=[O:37])[C@H:10]([CH2:33][CH2:34][S:35][CH3:36])[NH:11][C:12](=[O:32])[C@H:13]([CH2:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[NH:25][CH:24]=1)[NH2:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53790063HCID 53790063, compound

Product 1

HCID 70619178HCID 70619178, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

17.1 Parts N-t-butoxycarbonyl-L-tryptophyl-L-methionine benzyl ester is dissolved in 200 parts dioxane and treated with a 10 fold excess of 2N hydrochloric acid in dioxane for 10 minutes. Removal of the solvent under reduced pressure affords pure L-tryptophyl-L-methionine benzyl ester hydrochloride.

Workup

  1. customRemoval of the solvent under reduced pressure

Sources & evidence

ORD record
ord-e6c2cfd474ba4d4dbec3234ed9330946
Source dataset
uspto-grants-1978_05
Patent number
US04092304

Reaction notes

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