Benzenepropanenitrile, beta-hydroxy-beta-phenyl- → HCID 20326660, Verbindung

HRID 372792Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 372792
[OH:1][C:2]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][C:4]#[N:5].[CH2:18]([O:20][CH:21]([O:24][CH2:25][CH3:26])[CH2:22]I)[CH3:19]>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.C(Cl)Cl.[OH-].[Na+]>[CH2:18]([O:20][CH:21]([O:24][CH2:25][CH3:26])[CH2:22][O:1][C:2]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][C:4]#[N:5])[CH3:19]

Komponenten

6

Edukt 2

HCID 266076Benzenepropanenitrile, beta-hydroxy-beta-phenyl-HCID 125047911,1-Diethoxy-2-iodoethane

Produkt 1

HCID 20326660HCID 20326660, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 94433Tetrabutylammonium hydrogen sulfateKatalysatorHCID 6344DichloromethaneLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

To the solution of 11.15 g of 3-hydroxy-3,3-diphenylpropionitrile, 13.4 g of iodo acetaldehyde diethylacetal, and 0.9 g of tetra-n-butylammonium hydrogen sulfate in 40 ml of methylene chloride, 10 ml of 50% aqueous sodium hydroxide are added and the mixture is well stirred at room temperature for 24 hours. It is washed with water, dried and evaporated, to give the 2-(2-cyano-1,1-diphenylethoxy)-acetaldehyde diethylacetal as an oil which is sufficiently pure to be used without purification.

Aufarbeitung

  1. washIt is washed with water
  2. customdried
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-8cdc686b65734d95aaba20479c65d77a
Quelldatensatz
uspto-grants-1978_05
Patentnummer
US04092330

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