反应详情

This compound is prepared as described by Dressler and Kurland J.O.C. 29, 175 (1964). Under nitrogen gas, 500 g. indene plus 5 g. potassium t-butoxide are stirred and heated to 130°. 2-vinyl pyridine (220 g., 2.0 M) is added dropwise over a period of 1 hour keeping the temperature at 135°-145° C. during addition and for 2 hours after addition is completed. The reaction mixture is cooled and 25 ml. acetic acid is added, followed by filtration. A flash distillation yields 395 g. (84%) crude product boiling 160°-175°/0.3 mm. This is redistilled to give 353 g. (75%) of oil (3-[2(pyridyl)ethyl]indene) boiling point 135°-140°/0.1 mm.

1. customThis compound is prepared
2. temperatureheated to 130°
3. customat 135°-145° C.
4. additionduring addition
5. additionfor 2 hours after addition
6. temperatureThe reaction mixture is cooled
7. filtrationfollowed by filtration
8. distillationA flash distillation
9. customyields 395 g
10. customboiling 160°-175°
11. distillationThis is redistilled
12. customto give 353 g