HCID 67841292, compound → HCID 21614768, compound

HRID 372948Notes

Reaction equation

HRID 372948 reaction equation
[ClH:1].[C:2]1([CH2:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:20][CH2:21][C:22]([OH:24])=[O:23])CC2C=CC=CC=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C(O)C.[Pd]>[ClH:1].[C:2]1([CH2:8][CH2:9][CH2:10][CH2:11][NH:12][CH2:20][CH2:21][C:22]([OH:24])=[O:23])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 67841292HCID 67841292, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21614768HCID 21614768, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

27.13 g (0.085 mol) of this hydrochloride are hydrogenated in 300 ml of ethanol over 3 g of 5% palladium-on-charcoal catalyst at 20°-25° under normal pressure until the uptake of hydrogen has ended. The catalyst is filtered off with suction, the filtrate is evaporated and the residue is crystallized from acetone. 3-[N-(4-Phenylbutyl)-amino]-propionic acid hydrochloride is obtained, melting point 135°-137°.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. customthe filtrate is evaporated
  3. customthe residue is crystallized from acetone

Sources & evidence

ORD record
ord-c627d1651f6b43628d76fc6da56f658c
Source dataset
uspto-grants-1992_11
Patent number
US05162310

Reaction notes

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