Water → HCID 21459557, compound

HRID 372959Notes

Reaction equation

HRID 372959 reaction equation
[Br:1][C:2]1[C:6]([Br:7])=[C:5]([Br:8])[NH:4][C:3]=1[C:9]#[N:10].[C:11](=O)([O-])[O-].[K+].[K+].CI.O>CC(C)=O.C(COC)OC>[Br:1][C:2]1[C:6]([Br:7])=[C:5]([Br:8])[N:4]([CH3:11])[C:3]=1[C:9]#[N:10]

Participants

7

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 12040166HCID 12040166, compound

Product 1

HCID 21459557HCID 21459557, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 80711,2-DimethoxyethaneSolvent

Procedure

3,4,5-Tribromo-pyrrole-2-carbonitrile (1.0 g, 0.003 mol) is dissolved in a mixture of acetone and dimethoxyethane. Potassium carbonate (0.45 g, 0.0033 mol) is added followed by methyl iodide (0.478 g, 0.0033 mol). After stirring overnight at room temperature, the reaction mixture is poured into water and filtered. The filter cake is air dried to give the title compound as a white solid, 0.8 g (80%), mp 115°-119° C.

Workup

  1. filtrationfiltered
  2. customdried

Sources & evidence

ORD record
ord-a213a26c989b42c5aa4f9fcd1359161e
Source dataset
uspto-grants-1992_11
Patent number
US05162308

Reaction notes

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