反应详情

To the solution of 2 g of N-(4-phenylcyclohexyl)-N-cyclohexylmethylamine in dichloromethane was added 2 ml of pyridine and to the mixture was added a solution of 1.6 g of 2,6-diethylphenylisocyanate in 30 ml of dichloromethane dropwise. After the mixture was stirred at room temperature, to the solution was added diluted hydrochloric acid and extracted with ethyl acetate. The extract was washed with water, aqueous sodium hydrogencarbonate solution and saturated brine and then dried over magnesium sulfate. The solvent was distilled away in vacuo to give 2 g of crude crystals. The crystals were recrystallized from the mixture of ethyl acetate and hexane to give 1.2 g of N-(2,6-diethylphenyl)-N'-cyclohexylmethyl-N'-(4-phenylcyclohexyl)urea, melting at 166°-168° C.

1. extractionextracted with ethyl acetate
2. washThe extract was washed with water, aqueous sodium hydrogencarbonate solution and saturated brine
3. dry with materialdried over magnesium sulfate
4. distillationThe solvent was distilled away in vacuo
5. customto give 2 g of crude crystals
6. customThe crystals were recrystallized from the mixture of ethyl acetate and hexane