Water → HCID 21459535, compound

HRID 372960Notes

Reaction equation

HRID 372960 reaction equation
[Br:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([Br:9])[NH:4][C:3]=1[C:10]#[N:11].[C:12](=O)([O-])[O-].[K+].[K+].CI.O>CC(C)=O>[Br:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([Br:9])[N:4]([CH3:12])[C:3]=1[C:10]#[N:11]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 21459507HCID 21459507, compound

Product 1

HCID 21459535HCID 21459535, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A sample (1.0 g, 0.0036 mol) of 3,5-dibromopyrrole-2,4-dicarbonitrile is readily soluble in 20 mL of acetone. Anhydrous potassium carbonate (0.64 g, 0.0046 mol) is added, and while the slurry is stirred, methyl iodide (0.68 g, 0.0047 mol) is added. The reaction can be followed by Tlc. When the reaction is complete, the mixture is poured into water precipitating a white solid. The product (0.77 g, 74%) has mp 175°-178° C.

Workup

  1. customThe reaction

Sources & evidence

ORD record
ord-3ef38aad8a62414989d02967f05f6702
Source dataset
uspto-grants-1992_11
Patent number
US05162308

Reaction notes

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