Sodium Hydroxide → HCID 14127512, compound

HRID 372970Notes

Reaction equation

HRID 372970 reaction equation
C([O:3][C:4](=[O:30])[CH:5]([NH2:29])[CH2:6][C:7]1[CH:8]=[C:9]([C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)[CH:10]=[C:11]([CH2:13][P:14]([O:19][CH2:20][CH3:21])([O:16][CH2:17][CH3:18])=[O:15])[CH:12]=1)C.[OH-].[Na+]>O1CCCC1>[NH2:29][CH:5]([CH2:6][C:7]1[CH:8]=[C:9]([C:22]2[CH:23]=[CH:24][C:25]([Cl:28])=[CH:26][CH:27]=2)[CH:10]=[C:11]([CH2:13][P:14]([O:19][CH2:20][CH3:21])([O:16][CH2:17][CH3:18])=[O:15])[CH:12]=1)[C:4]([OH:30])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53963519HCID 53963519, compound

Product 1

HCID 14127512HCID 14127512, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4.6 g (±)-α-amino-3-(4'-chloro-5-(diethoxyphosphinyl)methyl [1.1'-biphenyl]-3-yl) propanoic acid ethyl ester, 1 equivalent of 1N sodium hydroxide and 4 parts by volume of tetrahydrofuran are stirred at room temperature for about 15 hours. The tetrahydrofuran is evaporated in vacuo. The residue is extracted with toluene/diethyl ether (1:1). The pH of the aqueous layer is adjusted to 5, whereby the heading compound crystallizes, m.p. 195°-205° (decomp.).

Workup

  1. customThe tetrahydrofuran is evaporated in vacuo
  2. extractionThe residue is extracted with toluene/diethyl ether (1:1)
  3. customcrystallizes

Sources & evidence

ORD record
ord-2bb195c6245e4684bbca376e2880d3b2
Source dataset
uspto-grants-1992_11
Patent number
US05162311

Reaction notes

Loading…