Hydrazine hydrate (1:1) → HCID 135670787, compound

HRID 372982Notes

Reaction equation

HRID 372982 reaction equation
CS[C:3]1[N:8]=[C:7]2[N:9]=[C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])[NH:11][C:12](=[O:13])[C:6]2=[CH:5][N:4]=1.O.[NH2:25][NH2:26]>C(O)C>[NH:25]([C:3]1[N:8]=[C:7]2[N:9]=[C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])[NH:11][C:12](=[O:13])[C:6]2=[CH:5][N:4]=1)[NH2:26]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 1355223017-Methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine

Product 1

HCID 135670787HCID 135670787, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A stirred mixture of 7-methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (1.31 g) and hydrazine hydrate (3 ml) in ethanol (30 ml) was heated under reflux for 3 hours to yield a yellow precipitate. The reaction mixture was cooled overnight and the yellow precipitate was collected and washed with ethanol and water to yield the title compound, 0.80 g, m.p. 219°-220° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. customto yield a yellow precipitate
  4. temperatureThe reaction mixture was cooled overnight
  5. customthe yellow precipitate was collected
  6. washwashed with ethanol and water

Sources & evidence

ORD record
ord-448d227366024f328b784ef9b49185d3
Source dataset
uspto-grants-1992_11
Patent number
US05162316

Reaction notes

Loading…