Acetic Anhydride → HCID 136029150, compound

HRID 372990Notes

Reaction equation

HRID 372990 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[N:8]=[C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH2:20][CH2:21][CH3:22])[NH:10][C:11](=[O:12])[C:5]2=[CH:4][N:3]=1.[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[C:23]([NH:1][C:2]1[N:7]=[C:6]2[N:8]=[C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH2:20][CH2:21][CH3:22])[NH:10][C:11](=[O:12])[C:5]2=[CH:4][N:3]=1)(=[O:25])[CH3:24]

Participants

3

Reactant 2

HCID 7918Acetic Anhydride2×HCID 135670763HCID 135670763, compound

Product 1

HCID 136029150HCID 136029150, compound

Procedure

A stirred mixture of 7-amino-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.59 g)and acetic anhydride (5 ml) was heated under reflux for 1.5 hours Excess acetic anhydride was removed under reduced pressure. The solid residue was washed with water and triturated with hot methanol to yield the title compound, 0.57 g, m.p. 273°-4° C.

Workup

  1. temperaturewas heated
  2. customwas removed under reduced pressure
  3. washThe solid residue was washed with water
  4. customtriturated with hot methanol

Sources & evidence

ORD record
ord-e011ccf28ad54dd8979a94c03026fa5b
Source dataset
uspto-grants-1992_11
Patent number
US05162316

Reaction notes

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