Ethanol → HCID 136170744, compound

HRID 372992Notes

Reaction equation

HRID 372992 reaction equation
CS[C:3]1[N:8]=[C:7]2[N:9]=[C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])[NH:11][C:12](=[O:13])[C:6]2=[CH:5][N:4]=1.[CH3:24][O:25][CH2:26][CH2:27][NH2:28].[CH2:29](O)C>>[CH3:24][O:25][CH:26]([CH3:29])[CH2:27][NH:28][C:3]1[N:8]=[C:7]2[N:9]=[C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])[NH:11][C:12](=[O:13])[C:6]2=[CH:5][N:4]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 80182-MethoxyethylamineHCID 1355223017-Methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine

Product 1

HCID 136170744HCID 136170744, compound

Procedure

In a similar manner to Example 13, reaction of 7-methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.41 g) and methoxyethylamine (1.04 g) in ethanol (15 ml) for 48 hours yielded the title compound, 0.38 g, m.p. 193°-4° C. (recrystallised twice from methanol).

Sources & evidence

ORD record
ord-622fbb8e592e46cbae2ade34da6a878b
Source dataset
uspto-grants-1992_11
Patent number
US05162316

Reaction notes

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