反应详情

A solution of 7-methylsulphonyl-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (229 mg) and diethylamine (420 mg) in dichloromethane (8 ml) was stirred at ambient temperature for 3 hours. The reaction mixture was eluted from a silica column with diethyl ether:chloroform (4:1) and the combined fractions containing product were evaporated under reduced pressure to yield an oil which on trituration with 40°-60° petroleum ether yielded the title compound, 85.5 mg, m.p. 116°-7° C.

1. washThe reaction mixture was eluted from a silica column with diethyl ether:chloroform (4:1)
2. additionthe combined fractions containing product
3. customwere evaporated under reduced pressure
4. customto yield an oil which on trituration with 40°-60° petroleum ether