Potassium Iodide → HCID 19811463, compound

HRID 373017Notes

Reaction equation

HRID 373017 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH:5]1[O:9][C:8](=[O:10])[N:7]([CH3:11])[CH2:6]1.Cl.[CH2:13]([O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[CH3:14].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(O)CCC>[CH2:13]([O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:23][CH2:24][N:25]([CH2:2][CH2:3][CH2:4][CH:5]2[O:9][C:8](=[O:10])[N:7]([CH3:11])[CH2:6]2)[CH2:26][CH2:27]1)[CH3:14]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 128624181-(2-Ethoxyphenyl)piperazine HydrochlorideHCID 198114995-(3-Chloropropyl)-3-methyl-2-oxazolidinone

Product 1

HCID 19811463HCID 19811463, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

Following the procedure of Example 5, a mixture of 5-(3-chloropropyl)-3-methyl-2-oxazolidinone (5.0 g, 0.0282 mol), 1-(2-ethoxyphenyl)piperazine monohydrochloride (6.86 g, 0.0282 mol), potassium carbonate (15.62 g, 0.113 mol), and potassium iodide (1.0 g) in n-butanol (100 mL) gave an oil (4.5 g, 46% yield). The oil was triturated in warm isopropyl ether and the resulting suspension was stirred at room temperature. The solid was collected by filtration, rinsed with light pet ether and dried under high vacuum to give 2.58 g, mp 79°-81° C.

Sources & evidence

ORD record
ord-ec36f824292648b98de83b958f083960
Source dataset
uspto-grants-1992_11
Patent number
US05162322

Reaction notes

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