反应详情

Following the procedure of Example 5, a mixture of 5-(2-chlorobutyl)-3-methyl-2-oxazolidinone (5.2 g, 0.0272 mol), 1-(2-ethoxyphenyl)piperazine monohydrochloride (6.61 g, 0.0272 mol), potassium carbonate (15.05 g, 0.109 mol), and potassium iodide (1.0 g) in n-butanol (100 mL) gave an oil which was dissolved in a mixture of ethyl acetate/isopropyl ether/light pet ether (removing the impurities by filtration) and acidified with ethereal hydrogen chloride. The mixture was evaporated under reduced pressure and recrystallized once from isopropanol/methanol/isopropyl ether and then from isopropanol/isopropyl ether and dried under high vacuum at 60° C. to give 1.18 g (10% yield), mp 207°-212° C.

1. customgave an oil which
2. customremoving the impurities
3. filtrationby filtration) and
4. customThe mixture was evaporated under reduced pressure
5. customrecrystallized once from isopropanol/methanol/isopropyl ether
6. dry with materialfrom isopropanol/isopropyl ether and dried under high vacuum at 60° C.
7. customto give 1.18 g (10% yield), mp 207°-212° C.